The glucose-regulated proteins: stress induction and clinical applications.
نویسنده
چکیده
A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is the induction of members of the glucose-regulated protein (Grp) family. The induction of mammalian Grp proteins in response to ER stress involves a complex network of regulators and novel mechanisms. The elucidation of Grp function and regulation opens up new therapeutic approaches to diseases associated with ER stress and cancer.
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ورودعنوان ژورنال:
- Trends in biochemical sciences
دوره 26 8 شماره
صفحات -
تاریخ انتشار 2001